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Abnormal microglial activation, oxidative stress, and neuronal death are also associated with the progression of the disease
This is likely due to the more established CKD-specific evidence base available for SGLT2is [10,11,12], and the fact that FLOW evaluated semaglutide in patients receiving prior guideline-directed standard of care, limiting generalisability to GLP-1 RAs more broadly as a first-line therapy [8, 9]
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